Since the first case of human infection with the H7N9 virus was announced at the end of March, it has attracted close attention from the society. The latest issue of Nature also titled "Novel bird flu kills two in China", pointing out that this pathogen has no obvious pathogenicity in poultry , Which makes it difficult to carry out surveillance, and therefore gives it the opportunity to adapt better in the human body, and eventually cause large-scale outbreaks. Biological Communication's H7N9 avian influenza virus infection, the first infected person was an 87-year-old man from Shanghai, onset on February 19, died on March 4, the second was a 27-year-old man He became ill on March 27 and died on March 10. According to the latest statistics, as of 17:00 on April 6, a total of 18 confirmed cases of H7N9 avian influenza were reported nationwide, and 6 people died. The epidemic is currently in a state of dissemination, and no human-to-human transmission has been found. Biocom cracks the sequence to get first-hand clues: Nature publishes an article to focus on China's H7N9 human bird flu incident
Influenza virologist Pei Weishi from the University of Hong Kong said that H7N9 virus does not seem to cause serious diseases in birds, which has potential epidemic impact on public health, because this virus can be spread without detection in poultry. A virus library, which triggered a large-scale human epidemic without warning. A highly pathogenic virus such as Bitong H5N1 is easy to find because it caused a large-scale outbreak of poultry and can also be controlled by culling, but to control H7N9 like this has no signs of spreading in birds Viruses, it is very difficult, "This is indeed a big problem", "The problem is whether it is too late to fight".
At present, there have not been any reports of birds infected with H7 avian influenza in China recently. This may be because these infections have not yet shown serious diseases, or because the monitoring or reports are not in place. Pei Weishi believes that the key now is to trace the birds or other animals that cause human infection. Biological H7 virus is very common in wild birds, but it is not common in poultry, and the three previous cases are unlikely to have symptoms due to exposure to wild birds in such a short period of time, poultry It is still the most likely source of the virus, Tashiro said, but if H7N9 has developed mutations that can infect mammals, then pigs may be another source.
Influenza experts said that at present, all cases of severe pneumonia need to be tested, analyzed for viruses, and people who have been exposed to new infections, and researchers and public health personnel also need to pay close attention to progress. In addition, according to the latest news, China National Food and Drug Administration and the Drug Evaluation Center have deployed and approved the launch of China's self-developed new drug paramivir injection as the guideline to ensure national public health safety needs.
At present, the research team of Li Song from the Institute of Toxicology and Drugs of the Academy of Military Medical Sciences has analyzed the genome sequence of H7N9 virus in China against the H7N9 avian influenza epidemic in humans. %, Suggesting that neuraminidase inhibitors are effective for this outbreak. Paramivir is a new potent neuraminidase inhibitor, which is effective against HXNX influenza virus and has a significant therapeutic effect on newly developed H7N9 human avian influenza patients.
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