In order to prevent the influence of oxygen and water vapor on drugs and ensure that the drugs do not deteriorate during the effective period, the blister pack should have good barrier properties. In this regard, relevant national standards have made explicit provisions for this, which is an important indicator for all production companies.
Blister packaging, also known as water eye packaging, is the PTP (Press Through Packaging) packaging technology, which is one of the main forms of pharmaceutical packaging and is applicable to the mechanized packaging of solid pharmaceutical products. It has very obvious advantages, such as stable and reliable drugs, easy to achieve less measurement and series packaging, advanced technology, safety and health, convenient carrying and use, long storage period, good adaptability and appearance, as well as functions such as identification and anti-counterfeiting.
Blister packs are widely used in the packaging of solid medicines due to their advantages of good protection, transparency, convenience of use, and light weight. In order to prevent the influence of oxygen and water vapor on drugs and ensure that the drugs do not deteriorate during the effective period, the blister pack should have good barrier properties. In this regard, relevant national standards have made explicit provisions for this, which is an important indicator for all production companies. Next, Labthink Languang (Jinan Languang Electromechanical Technology Co., Ltd. 0531-85068566) combines the OX2/230 oxygen transmission rate test system and the W3/330 water vapor transmission rate test system to provide a brief introduction to the detection of the barrier properties of blister packs. .
First, blister packaging oxygen permeability detection
Blister packs are a method of wrapping a product between a blister formed by a transparent plastic sheet and a base plate (made of cardboard, a plastic film or sheet, aluminum foil or their composite material). The oxygen barrier performance of oxygen blister packaging materials is an important factor affecting the quality of the blister packaging products during the shelf life, and is also an important reference for analyzing the shelf life. The detection can solve the oxidation caused by oxygen sensitivity. Problems such as deterioration. Labthink's OX2/230 Oxygen Permeability Test System uses the Coulomb principle, which means that pre-treated blister samples are placed in the test chamber, oxygen flows on the outside of the blister pack, and high-purity nitrogen is in the blister pack. Inside the flow, due to the oxygen concentration gradient, oxygen molecules diffuse through the membrane from the outside of the bubble to the inside of the high-purity nitrogen gas and are carried by the flowing nitrogen to the sensor. The oxygen concentration measured by the sensor is analyzed to calculate The oxygen permeability and other parameters were used to evaluate the oxygen barrier performance of the test samples.
In addition, OX2/230 Oxygen Transmission Rate Test System adopts patented technology of three test chamber integrated blocks, computer control, automatic test, after clamping the sample, click on the test can be fully automatic test, automatic humidity, temperature The control of the indicators such as the flow rate, the automatic judgment of the end of the experiment and the issuance of the report. The instrument can also be connected to 9 satellites and complete testing of 30 samples (oxygen or water vapor) at a time, which has reached international advanced level in terms of automation degree of operation, test efficiency, detection resolution and detection limit. Level.
Second, blister packaging water vapor transmission rate detection
The detection of water vapor transmission rate refers to the detection of water vapor barrier properties of blister packaging materials. The ability of blister packaging to block water vapour performance is an important factor affecting the quality of blister packaging products during the shelf life, and is also an important reference for analyzing shelf life. Through this test, moisture mildew due to moisture vapour sensitivity can be solved. And other issues.
Labthink's W3/330 Water Vapor Transmission Rate Test System uses the Coulomb method (electrolytic analysis method), which means that pre-treated blisters are placed in the test chamber, and a certain humidity of nitrogen flows outside the blister pack. High-purity nitrogen flows on the inside of the blister pack. Due to the presence of a moisture gradient, water vapor molecules diffuse through the membrane from the outside of the blisters to the inside of the high-purity nitrogen and are carried by the flowing nitrogen to the sensor and measured by the sensor. The water vapor concentration reached was analyzed to calculate the water vapor transmission rate and other parameters to evaluate the barrier vapor performance of the test sample.
In addition, the W3/330 water vapor transmission rate test system adopts a patented technology of three test chamber integrated blocks, computer control, automatic test, and after the test pieces are clamped, the test can be fully automatic and the humidity can be automatically realized. , temperature, flow rate and other indicators of control, the end of the test automatically determine and issue a report. The instrument can also be connected to 9 satellites and complete testing of 30 samples (oxygen or water vapor) at a time, which greatly improves the testing efficiency and meets the needs of customers for high-efficiency and high-precision testing. At present, the equipment has reached the international advanced level in the degree of automation, test efficiency, detection resolution and other aspects, and some indicators remain in the lead.
Of course, after ensuring the barrier performance index of the blister packaging, it is necessary to control other indicators such as the sealing performance, the heat sealing strength of the packaging, and the impact resistance performance to ensure the quality of the products during the shelf life. Jinan Languang Electromechanical Technology Co., Ltd. would like to take this opportunity to increase exchanges and cooperation with enterprises and institutions in the industry.
Blister packaging, also known as water eye packaging, is the PTP (Press Through Packaging) packaging technology, which is one of the main forms of pharmaceutical packaging and is applicable to the mechanized packaging of solid pharmaceutical products. It has very obvious advantages, such as stable and reliable drugs, easy to achieve less measurement and series packaging, advanced technology, safety and health, convenient carrying and use, long storage period, good adaptability and appearance, as well as functions such as identification and anti-counterfeiting.
Blister packs are widely used in the packaging of solid medicines due to their advantages of good protection, transparency, convenience of use, and light weight. In order to prevent the influence of oxygen and water vapor on drugs and ensure that the drugs do not deteriorate during the effective period, the blister pack should have good barrier properties. In this regard, relevant national standards have made explicit provisions for this, which is an important indicator for all production companies. Next, Labthink Languang (Jinan Languang Electromechanical Technology Co., Ltd. 0531-85068566) combines the OX2/230 oxygen transmission rate test system and the W3/330 water vapor transmission rate test system to provide a brief introduction to the detection of the barrier properties of blister packs. .
First, blister packaging oxygen permeability detection
Blister packs are a method of wrapping a product between a blister formed by a transparent plastic sheet and a base plate (made of cardboard, a plastic film or sheet, aluminum foil or their composite material). The oxygen barrier performance of oxygen blister packaging materials is an important factor affecting the quality of the blister packaging products during the shelf life, and is also an important reference for analyzing the shelf life. The detection can solve the oxidation caused by oxygen sensitivity. Problems such as deterioration. Labthink's OX2/230 Oxygen Permeability Test System uses the Coulomb principle, which means that pre-treated blister samples are placed in the test chamber, oxygen flows on the outside of the blister pack, and high-purity nitrogen is in the blister pack. Inside the flow, due to the oxygen concentration gradient, oxygen molecules diffuse through the membrane from the outside of the bubble to the inside of the high-purity nitrogen gas and are carried by the flowing nitrogen to the sensor. The oxygen concentration measured by the sensor is analyzed to calculate The oxygen permeability and other parameters were used to evaluate the oxygen barrier performance of the test samples.
In addition, OX2/230 Oxygen Transmission Rate Test System adopts patented technology of three test chamber integrated blocks, computer control, automatic test, after clamping the sample, click on the test can be fully automatic test, automatic humidity, temperature The control of the indicators such as the flow rate, the automatic judgment of the end of the experiment and the issuance of the report. The instrument can also be connected to 9 satellites and complete testing of 30 samples (oxygen or water vapor) at a time, which has reached international advanced level in terms of automation degree of operation, test efficiency, detection resolution and detection limit. Level.
Second, blister packaging water vapor transmission rate detection
The detection of water vapor transmission rate refers to the detection of water vapor barrier properties of blister packaging materials. The ability of blister packaging to block water vapour performance is an important factor affecting the quality of blister packaging products during the shelf life, and is also an important reference for analyzing shelf life. Through this test, moisture mildew due to moisture vapour sensitivity can be solved. And other issues.
Labthink's W3/330 Water Vapor Transmission Rate Test System uses the Coulomb method (electrolytic analysis method), which means that pre-treated blisters are placed in the test chamber, and a certain humidity of nitrogen flows outside the blister pack. High-purity nitrogen flows on the inside of the blister pack. Due to the presence of a moisture gradient, water vapor molecules diffuse through the membrane from the outside of the blisters to the inside of the high-purity nitrogen and are carried by the flowing nitrogen to the sensor and measured by the sensor. The water vapor concentration reached was analyzed to calculate the water vapor transmission rate and other parameters to evaluate the barrier vapor performance of the test sample.
In addition, the W3/330 water vapor transmission rate test system adopts a patented technology of three test chamber integrated blocks, computer control, automatic test, and after the test pieces are clamped, the test can be fully automatic and the humidity can be automatically realized. , temperature, flow rate and other indicators of control, the end of the test automatically determine and issue a report. The instrument can also be connected to 9 satellites and complete testing of 30 samples (oxygen or water vapor) at a time, which greatly improves the testing efficiency and meets the needs of customers for high-efficiency and high-precision testing. At present, the equipment has reached the international advanced level in the degree of automation, test efficiency, detection resolution and other aspects, and some indicators remain in the lead.
Of course, after ensuring the barrier performance index of the blister packaging, it is necessary to control other indicators such as the sealing performance, the heat sealing strength of the packaging, and the impact resistance performance to ensure the quality of the products during the shelf life. Jinan Languang Electromechanical Technology Co., Ltd. would like to take this opportunity to increase exchanges and cooperation with enterprises and institutions in the industry.
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