Recently, the research result of Professor Zhu Jinxia from the School of Basic Medical Sciences of Capital Medical University, "Entacapone promotes cAMP-dependent colonic Cl- secretion in rats", was published online in the professional journal "Neurogastroenterology & Motility" (2009 IF 3.568).
The author of this article studied the mechanism of gastrointestinal side effects of Entacapone (Entacapone) using "non-damaging micro-measurement technology" (Entacapone is a drug developed by world-renowned pharmaceutical company Novartis for the treatment of Parkinson's disease, catechin Phenol-O-methyl transferase (COMT) inhibitors. About 10% of clinical users will experience diarrhea). This article found that entacapone can significantly increase the intracellular cAMP content of rat colonic mucosa, thereby increasing the rate of Cl- efflux. This process can be regulated by prostaglandins in the animal and the nervous system of the intestinal submucosa. This explains the reason why Ntacapone produces gastrointestinal incompatibility. The non-damage micro-measurement technology experiment in this paper was completed in cooperation between Capital Medical University and Xuyue Company.
This article is the first paper published by scholars of Capital Medical University using non-invasive micro-measurement technology, which fully shows that ion current information can play an important role in the research of drug-related fields. Non-damage micro-measurement technology not only introduces a new concept for basic research, but is also expected to directly provide services for pharmaceutical companies to develop new drugs.
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